Evidence map›Paper›PMID 40708990›Full record

ReviewAsiaIntervention2025

Mitral annular calcification in interventional cardiology: address all fears.

Kyriakos Dimitriadis, Christina Drikou, Chrysali-Eirini Georgoulea, Nikolaos Pyrpyris, Panagiotis Tsioufis, Panagiotis Iliakis, Eirini Beneki, Christina Chrysohoou, Mony Shuvy, Konstantinos Aznaouridis and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in AsiaIntervention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyriakos DimitriadisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Christina DrikouFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Chrysali-Eirini GeorgouleaFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos PyrpyrisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis TsioufisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis IliakisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Eirini BenekiFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Christina ChrysohoouFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Mony ShuvyJesselson Integrated Heart Center, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Konstantinos AznaouridisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantina AggeliFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos TsioufisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitral annular calcification (MAC) is a particularly challenging pathological condition that can prove difficult to address. It consists of calcium depositions in the mitral valve ring, secondary to chronic inflammation and complex molecular pathogenetic mechanisms of injury and cellular response. MAC has been associated with worse survival in patients with valvulopathies compared to individuals without MAC, as well as with an enhanced risk for cardiovascular events and all-cause mortality. MAC also complicates interventions in the aortic and mitral valves, with several reports showcasing suboptimal results after transcatheter aortic valve implantation (TAVI). For mitral interventions, it is currently being evaluated whether transcatheter edge-to-edge repair (TEER) or transcatheter mitral valve replacement (TVMR) would best suit these patients, in the presence of severe mitral regurgitation (MR), with both procedures showing benefit in early study results. However, the limitations of each procedure for certain phenotypes and anatomies necessitate more extensive research, aiming to identify the most suitable candidates for each intervention. The purpose of this review is, thus, to present a summary of the factors that affect MAC, explore available diagnostic and therapeutic approaches, and provide a framework to anticipate and overcome the potential challenges that may arise during MAC-associated mitral valve disease treatment.

Identifiers

PMID40708990
PMCPMC12285396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.