ArticleFrontiers in pediatrics2025
The effect of prophylactic FVIII infusion combined with personalized rehabilitation on joint health and quality of life in children with hemophilia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hemophilia, a genetic disorder characterized by deficiencies in clotting factors VIII or IX, often results in joint and muscle bleeding, leading to hemophilic arthropathy and reduced quality of life. While multidisciplinary teams (MDTs) are widely used in hemophilia management, personalized rehabilitation strategies for pediatric patients remain underexplored. This study aimed to evaluate a 12-week individualized rehabilitation program targeting joint health in pediatric hemophilia patients. Methods: This prospective study enrolled 59 children with hemophilia, implementing tailored rehabilitation plans based on specific joint pathologies. Assessments before and after treatment included joint ultrasound examinations (HEAD-US-C), Hemophilia Joint Health Scores (HJHS 2.1), and the CHO-KLAT tool for quality of life. Bleeding frequency was also recorded. Results: Post-treatment, median HEAD-US-C scores decreased from 5.00 to 1.00 ( Conclusion: Regular prophylactic FVIII administration combined with individualized rehabilitation significantly reduces joint bleeding and enhances joint function and quality of life in children with hemophilia. The MDT approach is integral to comprehensive care, but further studies are needed to assess the long-term efficacy and safety of this therapeutic strategy.
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