ArticleFrontiers in pediatrics2025
Risk factors and adverse outcomes of extubation failure in preterm infants ≤32 weeks with neonatal respiratory distress syndrome.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Invasive mechanical ventilation (IMV) is a critical intervention for neonatal respiratory distress syndrome (NRDS). However, the high incidence of extubation failure and its adverse impact on preterm outcomes make the optimal timing of extubation a key clinical concern. This study aimed to identify risk factors for initial IMV extubation failure and analyze associated adverse outcomes in neonates ≤32 weeks' gestation with NRDS, to provide evidence-based guidance for clinical decision-making. Method: A retrospective cohort study was conducted in the neonatal ICU (NICU) of Jiangxi Maternal and Child Health Hospital from January 2021 to May 2024, including neonates ≤32 weeks with NRDS who are required to receive IMV within 72 h postnatal. Patients were stratified into a success group ( Results: A total of 290 cases were included, comprising 228 in the successful extubation group and 62 in the failed extubation group, yielding an extubation failure rate of 21.4%. Univariate analysis revealed that the extubation failure group had significantly lower gestational age, birth weight, weight at extubation, and initial serum albumin levels ( Conclusion: Lower body weight at extubation, higher FiO₂, patent ductus arteriosus (PDA >1.5 mm), Grade 3 or higher intracranial hemorrhage, maternal
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