Evidence map›Paper›PMID 40708851›Full record

ArticleNAR genomics and bioinformatics2025

Generating realistic artificial human genomes using adversarial autoencoders.

Callum Burnard, Alban Mancheron, William Ritchie

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Generating synthetic genotypes using diffusion models.Bioinformatics (Oxford, England) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Callum BurnardInstitut de Génétique Humaine, 34094 Montpellier, France.ORCID https://orcid.org/0000-0002-9942-1547
Alban MancheronLaboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier, 34095 Montpellier, France.
William RitchieInstitut de Génétique Humaine, 34094 Montpellier, France.ORCID https://orcid.org/0000-0001-8162-1439

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A publicly available human genome is both valuable to researchers and a risk for its donor. Many actors could exploit it to extract information about the donor's health or that of their relatives. Recent efforts have employed artificial intelligence models to simulate genomic data, aiming to create synthetic datasets with scientific merit while preserving patient anonymity. Challenges arise due to the vast amount of data that constitute a complete human genome and the computational resources required. We present a dimension reduction method that combines artificial intelligence with our knowledge of

Indexed as

Artificial IntelligenceGenome, HumanGenomicsAlgorithmsAutoencoderHumansLinkage DisequilibriumMutation

Identifiers

PMID40708851
PMCPMC12288873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.