Evidence map›Paper›PMID 40708814›Full record

ArticleIn vitro models2025

Conductive biological materials for in vitro models: properties and sustainability implications.

Aleksandra Serafin, César R Casanova, Arvind K Singh Chandel, Rui L Reis, Joaquim Miguel Oliveira, Maurice N Collins

Abstract read
In one paragraph

Article in In vitro models, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksandra SerafinStokes Laboratories, Bernal Institute, School of Engineering, University of Limerick, Limerick, Ireland.
César R Casanova3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence On Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco Guimarães, Portugal.
Arvind K Singh ChandelStokes Laboratories, Bernal Institute, School of Engineering, University of Limerick, Limerick, Ireland.
Rui L Reis3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence On Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco Guimarães, Portugal.
Joaquim Miguel Oliveira3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence On Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco Guimarães, Portugal.
Maurice N CollinsStokes Laboratories, Bernal Institute, School of Engineering, University of Limerick, Limerick, Ireland.ORCID 0000-0003-2536-4508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of conductive biological materials into in vitro models represents a transformative approach to advancing biomedical research while addressing critical sustainability challenges. Traditional materials used in tissue engineering and disease modeling are often environmentally detrimental, derived from non-renewable resources, and limited in their ability to replicate the dynamic properties of native tissues. Conductive biological materials bridge this gap by offering a unique combination of biodegradability, sustainability, and functional properties, such as bioelectricity and biocompatibility, that are essential for mimicking physiological environments. Herein, the development and current applications of biodegradable conductive materials, including advanced polymers such as polyaniline and polypyrrole, carbon-based nanocomposites, and renewable biopolymers derived from lignin and cellulose, are overviewed. These materials not only reduce the ecological footprint of biomedical research but also enable the precise simulation of electrical signaling in tissues, such as cardiac, neural, and muscular systems, thereby enhancing the physiological relevance of in vitro models. Their integration into three-dimensional (3D) tissue constructs, organ-on-chip platforms, and bioprinting technologies facilitates the development of patient-specific models, paving the way for personalized therapeutic and diagnostic applications. In addition to advancing biomedical precision, these materials align with global efforts to implement circular economy principles in research, promoting resource efficiency and waste reduction. By combining environmental responsibility with state-of-the-art functionality, conductive biological materials are redefining the future of in vitro 3D models and research, accelerating innovation in regenerative medicine, drug development, and disease modeling while fostering a sustainable framework for scientific discovery.

Indexed as

Biodegradable materialsConductive materialsIn vitro modelsSustainability

Identifiers

PMID40708814
PMCPMC12283528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.