ArticleFrontiers in human neuroscience2025
Requirement of a complex motor task to identify neuroplastic changes in motor control of the lower extremity in patients with anterior cruciate ligament reconstruction: a fNIRS study.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Distinct Movement-Related Cortical Control Following Anterior Cruciate Ligament Injury: A Scoping Review.Sports medicine - open · 2026Review
- Biochemical Pathways of Neuroplasticity in Sport Skill Acquisition: From Neuroscience to Coaching Practice.Brain sciences · 2026Review
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Abstract
Introduction: Neuromuscular control is a crucial component in restoring dynamic joint stability following anterior cruciate ligament reconstruction (ACLR). The central nervous system, as the primary control center, is known to exhibit neuroplastic changes. However, motor tasks used to assess brain function in ACLR are often limited to simple and static movements. The current study aimed to compare brain activation between patients with ACLR (ACLR group) and healthy controls (CONT group) during both simple and complex motor tasks and to examine the relationship between brain activity and clinical functions to explore the underlying mechanisms of neuroplasticity. Methods: A total of 35 patients with ACLR and 25 healthy controls participated in this study. Functional near-infrared spectroscopy was used to capture real-time brain activation during knee flexion-extension (K-FE) and single-leg squat (SLS) tasks. Clinical assessments included quadriceps strength, single-leg hop, and self-reported functional outcomes. A two-way mixed-design ANOVA was conducted with one between-subject factor (group) and one within-subject factor (task). The dependent variable was the change in oxyhemoglobin concentration (ΔHbO) across six brain regions. Results: For the affected limb tasks, the Primary Somatosensory Cortex (S1) and Supramarginal Gyrus (SMG) showed significant main group effects ( Conclusion: Brain activation increased with task difficulty. Patients with ACLR showed lower somatosensory cortex activation during affected limb tasks. Their task adaptation was weaker than that of healthy controls, suggesting deficits in proprioception and a lack of neural resources for adaptation to task complexity. The significant interaction effects observed during the contralateral limb tasks indicated the compensatory role of the contralateral limb. These conclusions were supported by correlations with clinical outcomes.
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