ReviewFrontiers in physiology2025
Multiple roles of ALDH1 in health and disease.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Rhein from a traditional herbal formula attenuates hepatic fibrosis via ALDH1A3-mediated retinoic acid metabolism.Chinese medicine · 2026Article
- Review
- Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry.Drug metabolism reviews · 2026Article
- ALDH1a3 Protects Against Iron Overload-Induced Oxidative Stress and Mitochondrial Impairment in Renal Tubular Epithelial Cells.Antioxidants (Basel, Switzerland) · 2026Article
- Neuroprotective Effects of Cerium Oxide Nanoparticles During Spaceflight.Small science · 2026Article
- In Vitro Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2026Article
- Immunohistochemical Evaluation of ALDH1 and Maspin in Oral Potentially Malignant Disorders and Oral Carcinoma.Biomedicines · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldehyde dehydrogenase 1 (ALDH1) is an important aldehyde-metabolizing enzyme that plays a key role in various biological processes, such as regulating cellular growth, modulating retinoic acid (RA) signaling pathways, and contributing to stem cell function. It is recognized as a crucial biomarker not only because of its significant involvement in the occurrence and development of various cancers but also because it is an important prognostic indicator for cancer progression. Furthermore, recent research has provided substantial evidence that the multiple roles of ALDH1 extend beyond cancer, with significant progress in understanding its mechanisms in other diseases and its clinical applications. These findings provide potential therapeutic targets for the future treatment of other diseases. In this review, we summarize the current understanding of the biological functions of ALDH1, the molecular mechanisms of its transcription and regulation, and the progress in cancer research related to the ALDH1 family. We not only discuss the mechanisms of ALDH1 in cancer but also its research development and potential pathological mechanisms in other diseases. The role of ALDH1 in various diseases is complex, and its expression levels are highly important for disease diagnosis, treatment, and prognosis. Future in-depth studies on ALDH1 functions are expected to provide new strategies and directions for the treatment of related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.