Evidence map›Paper›PMID 40708768›Full record

ArticleHeart international2025

Multidimensional Determinants of Functional Status in Patients with Heart Failure.

Jia-Rong Wu, Abigail Latimer, Ashmita Thapa, Cynthia Arslanian-Engoren, Jennifer L Smith, Jessica Harman Thompson, Chin-Yen Lin, JungHee Kang, Muna Hammash, Muhammad I Amin and 4 more

Abstract read
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In one paragraph

Article in Heart international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jia-Rong WuCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Abigail LatimerCollege of Social Work, University of Kentucky, Lexington, KY, USA.
Ashmita ThapaCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Cynthia Arslanian-EngorenCollege of Nursing, University of Michigan, Ann Arbor, MI, USA.
Jennifer L SmithCollege of Nursing, University of Tennessee, Knoxville, TN, USA.
Jessica Harman ThompsonCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Chin-Yen LinCollege of Nursing, Auburn University, Auburn, AL, USA.
JungHee KangCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Muna HammashUniversity of Sharjah, Sharjah, United Arab Emirates.
Muhammad I AminCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Martha J BiddleCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Kyoung Suk LeeCollege of Nursing, Seoul National University, Seoul, South Korea.
Seongkum HeoCollege of Nursing, Mercer University, Atlanta, GA, USA.
Debra K MoserCollege of Nursing, University of Tennessee, Knoxville, TN, USA.

Funding

Investigator Development CoreP50MD017338 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MEHTA, TAPAN S · 2021 to 2025
$27.7M
NIMHD NIH HHS P50 MD017338
6 · The paper itself

Abstract

Introduction: Functional status is a predictor of rehospitalization and mortality in patients with heart failure (HF). The purpose of this study was to test the variables in the Multidimensional Model of Functional Status (MMFS) as determinants of functional status. Methods: Using structural equation modelling, we analysed data from 520 patients with HF to determine the best multivariate model of functional status. In the MMFS, the potential determinants of functional status include demographic, clinical, psychosocial, behavioural and symptom burden variables. We measured functional status using the Duke Activity Status Index. Other variables were collected by standardized questionnaires and patient interviews. Results: Patients who were older, less educated, or had greater comorbidity burden or greater symptom burden had worse functional status. Sex, body mass index, depression, anxiety and social support were indirectly associated with functional status mediated by symptom burden. Being married was indirectly associated with better functional status via the pathways of more social support and fewer depressive symptoms through lower symptom burden. Conclusion: Multidimensional variables proposed in the MMFS were directly and indirectly associated with functional status. Among these variables, symptom burden is the most important mediator. Targeting these variables, especially symptom burden, may improve patients' functional status.

Indexed as

Anxietydepressiondeterminantsfunctional statusheart failuremodelself-caresymptom burden

Identifiers

PMID40708768
PMCPMC12285664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.