ReviewFrontiers in endocrinology2025
Bile acids and gestational diabetes mellitus: exploring the link and implications - a review.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Pregnancy-related disorders: molecular mechanisms and management.Molecular biomedicine · 2026Review
- Gestational diabetes: from pathogenesis to therapeutic intervention.Diabetology & metabolic syndrome · 2026Review
- Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus.Cardiovascular diabetology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) represents a prevalent metabolic disorder related to pregnancy, posing significant risks to both the expecting mother and the developing fetus. Recent research indicates a potential connection between bile acids (BAs) and GDM, such as lithocholic acid (LCA), β-muricholic acid (β-MCA), and 6,7-diketolithocholic acid (6,7-diketoLCA), have been found to be significantly increased in GDM individuals, thereby with the potential to reveal their involvement in glucose metabolism and the underlying mechanisms of GDM development. Additionally, BAs have emerged as vital signaling molecules that regulate glucose and lipid metabolism by interacting with Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), highlighting their potential as novel therapeutic targets for GDM management. The aim of this manuscript is to comprehensively review the current understanding of the relationship between BAs and GDM, delving into their potential mechanistic roles, diagnostic significance, and possible therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.