Evidence map›Paper›PMID 40708706›Full record

ArticleToxicology research2025

Network toxicology and molecular docking strategy for Analyzing the toxicity and mechanisms of Bisphenol a in hypertension.

Wenjie Zhang, Yinming Zhang, Jiawei Tang, Ji Wu, Jun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenjie ZhangDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange Road, Xicheng District, Beijing 100053, China.
Yinming ZhangDepartment of Emergency, Yankuang New Journey General Hospital, No. 560, Kuangjiandonglu Road, Zoucheng 273500, Shandong Province, China.
Jiawei TangSchool of Computer Science, Beijing University of Posts and Telecommunications, No. 10, Xitucheng Road, Haidian District, Beijing 100876, China.
Ji WuDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange Road, Xicheng District, Beijing 100053, China.
Jun LiDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange Road, Xicheng District, Beijing 100053, China.ORCID https://orcid.org/0000-0003-1334-6281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental pollution is an important risk factor for hypertension, and bisphenol A (BPA) is a prevalent environmental contaminant. This study aimed to investigate the potential toxicity of BPA and the underlying molecular mechanisms of BPA-induced hypertension through network toxicology and molecular docking. Initially, we predicted that BPA would be cardiotoxic. We subsequently identified 51 potential targets and extracted 14 core targets of the effects of BPA on hypertension. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis demonstrated that these core targets were involved primarily in the estrogen signaling pathway and the calcium signaling pathway. Furthermore, molecular docking confirmed the binding capacity of BPA to these core targets, with

Indexed as

Bisphenol acardiotoxicityhypertensionmolecular mechanism

Identifiers

PMID40708706
PMCPMC12284880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.