Evidence map›Paper›PMID 40708646›Full record

ArticleFrontiers in medicine2025

Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes.

Binura Taurbekova, Abay Tursunov, Aida Kabibulatova, Alimzhan Muxunov, Assel Issabayeva, Kuralay Atageldiyeva, Kamilya Sydykova, Aigul Durmanova, Akbayan Markabayeva, Andrey Starodubov and 3 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Binura TaurbekovaDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Abay TursunovDepartment of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Aida KabibulatovaDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Alimzhan MuxunovDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Assel IssabayevaDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Kuralay AtageldiyevaDepartment of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Kamilya SydykovaDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Aigul DurmanovaDepartment of Medicine, "University Medical Center" Corporate Fund, Astana, Kazakhstan.
Akbayan MarkabayevaMedical Center Hospital of the President's Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan.
Andrey Starodubov"B.B.NURA" Hospitals Group, Astana, Kazakhstan.
Kymbat MukhtarovaDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Wassim Y AlmawiScience Faculty of Tunisia, Université de Tunis El Manar, Tunis, Tunisia.
Antonio Sarria-SantameraDepartment of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Diabetic kidney disease (DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM). Given vitamin D's roles in glucose metabolism and renal function, this study investigated associations between common variants in vitamin D pathway genes ( Methods: This case-control study included 170 patients with DKD, 157 patients without DKD, and 118 normoglycemic healthy controls. Four single nucleotide polymorphisms (SNPs) in the Results: The Discussion: These findings suggest that individual variants in vitamin D pathway genes may serve as potential genetic markers for DKD risk stratification. In addition, haplotype analysis may offer complementary insight into genetic contributions to disease susceptibility.

Indexed as

CYP27A1CYP2R1diabetic nephropathyGCpolymorphismstype 2 diabetes mellitus

Identifiers

PMID40708646
PMCPMC12286948

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