Evidence map›Paper›PMID 40708539›Full record

ArticleActa biochimica et biophysica Sinica2025

Rhamnose alleviates the proinflammatory response during endotoxemia via the CEACAM1/LGALS9-p38 axis.

Rongjuan Wei, Tao Zhong, Ke Deng, Xianglong Zhang, Dongping Li, Meiling Chen, Ping Chang, Peng Wu, Zhanguo Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongjuan WeiDepartment of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Tao ZhongDepartment of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Ke DengDepartment of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Xianglong ZhangDepartment of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Dongping LiDepartment of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Meiling ChenDepartment of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Ping ChangDepartment of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Peng WuDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
Zhanguo LiuDepartment of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota plays an important role in orchestrating the host immune response. We previously reported that gut microbiota-derived rhamnose enhances the phagocytosis of macrophages, upon which we further asked whether rhamnose has modulatory effects on inflammation. Here, we show that, in an LPS-induced endotoxic mouse model, plasma rhamnose levels are increased. This bacteria-derived sugar alone does not impact inflammatory cytokine homeostasis or cause organ damage. In contrast, it is able to alleviate endotoxin-induced systemic inflammation and organ damage. Mechanistically, in macrophages

Indexed as

CEACAM1endotoxemiainfectionp38rhamnose

Identifiers

PMID40708539
PMCPMC12747936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.