ArticleJournal of periodontal research2025
Limosilactobacillus reuteri-Fusobacterium nucleatum Interactions Modulate Biofilm Composition and Immunogenicity.
Article in Journal of periodontal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Exploratory randomized trial of Weissella cibaria CMU and oral microbiome changes in peri implant mucositis.Scientific reports · 2026Trial
- Probiotics in Mitigating Pesticide Toxicity in Teleost Fish: Mechanisms and Prospects.Probiotics and antimicrobial proteins · 2026Review
- Article
- Interrogation of imaging-based interspecies dynamics in the oral microbiome.Journal of oral microbiology · 2026Review
- Microbial Coaggregation in the Oral Cavity: Molecular Interactions and Current Insights.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
aimThe interactions between Limosilactobacillus reuteri and oral bacteria are poorly understood. This study seeks to characterize how two strains of L. reuteri coaggregate with Fusobacterium nucleatum, determining the impact on the biofilm composition and immunogenicity.
methodsA series of in vitro experiments was conducted using L. reuteri DSM 17938 and ATCC PTA 5289, Fusobacterium nucleatum ATCC 25586, and Porphyromonas gingivalis W50. The coaggregation between individual strains of L. reuteri, F. nucleatum, and P. gingivalis was evaluated using the tube coaggregation assay and confocal microscopy. Biofilm compositions were determined by confocal microscopy and culture. The effect of coaggregation on the immunogenicity of L. reuteri-F. nucleatum aggregates were evaluated using periodontal ligament fibroblasts, oral epithelial cells, and monocytes.
resultsBoth L. reuteri DSM and PTA strains demonstrated coaggregation with F. nucleatum. This interaction reduced the amount of F. nucleatum in biofilm by 1000-fold. Additionally, the coaggregation between L. reuteri and F. nucleatum lowered its immunogenicity. Furthermore, the coaggregation of L. reuteri with F. nucleatum led to a 50% reduction in the amount of P. gingivalis present in the biofilm.
conclusionThis study demonstrates novel mechanisms through which L. reuteri can exert its effects as a probiotic. The coaggregation with L. reuteri modulates the immunogenicity of F. nucleatum and impairs its ability to serve as the bridging species, altering the biofilm composition, thus limiting the extent of dysbiosis.
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