Evidence map›Paper›PMID 40708308›Full record

ArticleTransfusion2025

Rare case of warm IgM autoimmune hemolytic anemia.

Bryan Tordon, Nour Alhomsi, Ali Iqbal, Azim Gangji, Gwen Clarke, Shuoyan Ning

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bryan TordonDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Nour AlhomsiHamilton Health Sciences, Transfusion Medicine, Hamilton, Ontario, Canada.
Ali IqbalDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Azim GangjiDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Gwen ClarkeDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Shuoyan NingHamilton Health Sciences, Transfusion Medicine, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-7675-4058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold agglutinins are IgM-mediated autoimmune hemolytic processes that most often cause destruction of red blood cells at colder temperatures. Here we describe a case of a patient with history of living donor renal transplantation that developed an atypical autoantibody causing profound anemia and hemolysis which, although IgM in nature, reacted best at warmer temperatures and was caused by a lymphoproliferative disorder. The investigations and serological findings here raise awareness to less common forms of autoimmune hemolytic disorders and describe specialized tests that can help uncover these antibodies. This case also highlights a rare presentation of post-transplant lymphoproliferative disorder manifesting clinically as hemolytic anemia.

Indexed as

Anemia, Hemolytic, AutoimmuneImmunoglobulin MKidney TransplantationAutoantibodiesHumansLymphoproliferative DisordersAutoantibodiesImmunoglobulin Mimmunohematology (RBC serology, blood groups)transfusion practices (adult)transfusion service operations

Identifiers

PMID40708308
PMCPMC12432800

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.