Evidence map›Paper›PMID 40708051›Full record

ArticleBMC global and public health2025

Vaccination as a strategy for Chlamydia trachomatis control: a global mathematical modeling analysis.

Monia Makhoul, Laith J Abu-Raddad

Abstract read
In one paragraph

Article in BMC global and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Monia MakhoulInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, P.O. Box 24144, Doha, Qatar. mom2039@qatar-med.cornell.edu.
Laith J Abu-RaddadInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, P.O. Box 24144, Doha, Qatar. lja2002@qatar-med.cornell.edu.

Funding

Qatar Research Development and Innovation Council ARG01-0522-230273Weill Cornell Medicine - Qatar Biostatistics, Epidemiology, and Biomathematics Research Core
6 · The paper itself

Abstract

backgroundChlamydia trachomatis (CT) is among the most common sexually transmitted infections and is associated with substantial health and economic burdens. Vaccination may offer a promising strategy for its global control.

methodsA deterministic, age-structured mathematical model was applied to assess the global impact of a hypothetical CT vaccine. The analysis explored a range of assumptions for vaccine efficacy against infection acquisition (

resultsVaccinating individuals aged 15-49 years beginning in 2030 with a vaccine of

conclusionsVaccination against CT can substantially reduce global infection burden, even with moderate efficacy. Impact is enhanced by targeted strategies, with adolescent vaccination aiding long-term control and catch-up programs ensuring immediate benefit. These findings highlight the urgency of vaccine development and integration into public health efforts.

Indexed as

Cost-effectivenessGlobal healthNumber needed to vaccinateSexually transmitted infectionTransmission dynamicsVaccine impact

Identifiers

PMID40708051
PMCPMC12291290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.