Evidence map›Paper›PMID 40708042›Full record

ReviewBiotechnology for biofuels and bioproducts2025

Nature's laboratory: plant metabolic engineering methods using phenylpropanoids as a case study.

Caroline Van Beirs, Ilias El Houari, Bartel Vanholme

Abstract readReview
In one paragraph

Review in Biotechnology for biofuels and bioproducts, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Microbial Metabolism: Primary and Secondary Metabolites.Progress in molecular and subcellular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Caroline Van BeirsDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052, Ghent, Belgium.ORCID http://orcid.org/0000-0002-6376-2307
Ilias El HouariWhitehead Institute for Biomedical Research, Whitehead Institute, 02141, Cambridge, USA.ORCID http://orcid.org/0000-0003-3985-4196
Bartel VanholmeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052, Ghent, Belgium. bartel.vanholme@psb.vib-ugent.be.ORCID http://orcid.org/0000-0002-7214-7170

Funding

Fonds voor Wetenschappelijk Onderzoek - Vlaanderen 11D8222N
6 · The paper itself

Abstract

Plant specialised metabolism generates a vast array of compounds with significant potential across agriculture, medicine, cosmetics, and the food industry. A key challenge lies in optimising their production in the plant, as these compounds are often present in trace amounts in a complex metabolic cocktail. Given their high economic value, extensive efforts have been made to elucidate their biosynthetic pathways and pinpoint key regulatory and enzymatic targets. This knowledge has been applied for metabolic engineering to enhance the carbon flux towards metabolites of interest, thereby broadening the utility of plants as a source of high-value compounds. This review examines different metabolic engineering strategies employed today using the phenylpropanoid pathway as a case study and highlights the potential of integrating plant and microbial research to drive cross-disciplinary innovation.

Indexed as

Metabolic engineeringPhenylpropanoidsPlantsSpecialised metabolites

Identifiers

PMID40708042
PMCPMC12288276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.