Evidence map›Paper›PMID 40707956›Full record

ArticleTrials2025

The effect of repetitive transcranial magnetic stimulation (rTMS) on perioperative neurocognitive disorders in patients after cardiac surgery: study protocol for a randomized controlled trial.

Jing Wang, Xuyang Wang, Sijie Li, Jinrong Yang, Xiang Yan, Jie Gao, Xiuqin Jia, Long Zuo, Anshi Wu, Changwei Wei

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05668559 (The Effects of rTMS on Postoperative Cognitive Function in Patients After Cardiac Surgery), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05668559 naunknown statusnot on this map

The Effects of rTMS on Postoperative Cognitive Function in Patients After Cardiac Surgery

TypeinterventionalSponsorAnshi WuRan2023 to 2026Enrolled280ConditionsPostoperative Cognitive Dysfunction, Repetitive Transcranial Magnetic StimulationArmsrepetitive transcranial magnetic stimulation, Sham Stimulation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing Wang *Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Xuyang Wang *Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Sijie LiDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Jinrong YangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Xiang YanDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Jie GaoDepartment of Cardiac Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Xiuqin JiaDepartment of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Long ZuoDepartment of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Anshi WuDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Changwei WeiDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China. changwei.wei@ccmu.edu.cn.ORCID http://orcid.org/0000-0001-5652-600X

Funding

Capital Medical University CYDXK202210
6 · The paper itself

Abstract

introductionPerioperative neurocognitive disorders (PND) is one of the most common postoperative complications among elderly patients (above 65 years old) undergoing cardiac surgery. However, thus far, there have not been any effective therapies for managing PND. Recent research has shown that repetitive transcranial magnetic stimulation (rTMS) alters brain plasticity and improves cognitive function in several neurodegenerative disorders and psychiatric disorders. However, the potential benefits of rTMS in reducing PND in patients undergoing cardiac surgery have not been investigated. Therefore, the current protocol is designed to determine whether rTMS can reduce the incidence of PND in patients undergoing cardiac surgery. METHODS AND ANALYSIS: The study will be a single-blinded, randomized controlled trial. Participants undergoing elective cardiac surgery will be randomized to receive either rTMS or sham stimulation with focal figure-of-eight coils over the right dorsolateral prefrontal cortex. A series of neuropsychological tests will be completed to evaluate cognitive function in surgery patients before, on day 7, and on day 30 after cardiac surgery. The primary outcome is the prevalence of PND in cardiac surgery patients. The secondary outcomes will be the incidence of postoperative delirium, pain, sleep quality, depressive symptoms, activities of daily living, length of hospital stay and ICU length of stay, and rate of complication and mortality during the hospital stay. ETHICS AND DISSEMINATION: Beijing Chaoyang Hospital Ethics Committee approved this study and has the number 2022-ke-487. It is registered with Clinical Trials (trial number NCT05668559). Informed consent must be provided by all participants. The study result will be published in a peer-reviewed journal.

trial registrationNCT05668559. Registered on June 6, 2022.

Indexed as

Cardiac Surgical ProceduresNeurocognitive DisordersPostoperative Cognitive ComplicationsTranscranial Magnetic StimulationAgedCognitionFemaleHumansMaleNeuropsychological TestsRandomized Controlled Trials as TopicSingle-Blind MethodTime FactorsTreatment OutcomeClinical trialsPerioperative neurocognitive disorders (PND)ProtocolPsychiatryTranscranial magnetic stimulation (TMS)

Identifiers

PMID40707956
PMCPMC12291346

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.