ArticleBMC endocrine disorders2025
Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association Between Polycystic Ovary Syndrome and Markers of Subclinical Atherosclerosis in Premenopausal Women: A Systematic Review.Journal of clinical medicine · 2026Review
- Assessing the Discriminative Power of Metabolic Indices for PMOS Detection in Normal-Weight Women.International journal of women's health · 2026Article
- Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases.Frontiers in endocrinology · 2026Review
- Formulation principles and mechanisms of TCM patent prescriptions for PCOS: A data mining study from CNIPA.Medicine · 2025Article
- Metabolic and Inflammatory Adipokine Profiles in PCOS: A Focus on Adiposity, Insulin Resistance, and Atherogenic Risk.International journal of molecular sciences · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundPolycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism contribute to an increased risk of atherogenesis.
methodsOur study was conducted retrospectively on 347 women with PCOS and 132 healthy women who presented at our clinic. The impact of PCOS on the atherogenic plasma index (AIP) was assessed using multivariable linear regression analysis.
resultsThe AIP was significantly greater in women with PCOS than in controls (p-value < 0.001). A marked increase in AIP was observed when the body mass index (BMI) was ≥ 35 kg/m² (p-value < 0.001). AIP was positively correlated with BMI (r = 0.174, p-value = 0.001) and the homeostatic model assessment for insulin resistance (HOMA-IR) score (r = 0.294, p-value < 0.001). In the multivariable linear regression model including all participants, PCOS diagnosis (B = 0.146, 95% CI = 0.082-0.210; p-value < 0.001) and HOMA-IR (B = 0.017, 95% CI = 0.011-0.022; p-value < 0.001) independently predicted higher AIP. These findings identify PCOS and insulin resistance as independent risk factors for increased atherogenicity.
conclusionsPCOS diagnosis and HOMA-IR are independent risk factors for increased atherogenicity. The increased atherogenic burden in women with PCOS can be assessed by the AIP. A significant increase in atherogenicity was observed in patients with a BMI of 35 kg/m² or higher.
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