Evidence map›Paper›PMID 40707914›Full record

ArticleBMC genomics2025

Genetic fine-mapping of body weight and size traits at 120 days of age in Lion-head geese.

Zhirong Huang, Liyun Zhang, Maojun Luo, Nian Liu, Zhongping Wu, Xumeng Zhang, Junpeng Chen, Zhenping Lin, Yunmao Huang, Yunbo Tian and 2 more

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In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

12 authors.

Zhirong Huang *College of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Liyun Zhang *College of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Maojun LuoCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Nian LiuCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Zhongping WuCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Xumeng ZhangCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Junpeng ChenBaisha Poultry and Livestock Origin Research Institute, Shantou, 515821, People's Republic of China.
Zhenping LinBaisha Poultry and Livestock Origin Research Institute, Shantou, 515821, People's Republic of China.
Yunmao HuangCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Yunbo TianCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China.
Jicai JiangDepartment of Animal Science, North Carolina State University, Raleigh, NC, 27695, USA.
Xiujin LiCollege of Animal Science Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, People's Republic of China. lixiujin996@126.com.

Funding

Seed Industry Vitalization of Guangdong Province 2023-XDY-00-001Special Project for Research and Development in Key areas of Guangdong Province 2020B020222003Young innovative talents projects of Ordinary Universities in Guangdong Province 2022KQNCX028
6 · The paper itself

Abstract

backgroundThe Lion-head goose is one of the largest goose breeds all over the word. Body weight and body size traits at 120 days of age (i.e. the slaughter age) are economically important traits, which directly affect the profit of Lion-head goose industry. However, so far few studies have explored the genetic basis of these traits. This study for the first time integrated the single-SNP genome-wide association study (GWAS) and genetic fine-mapping based on whole-genome sequencing data to investigate the genetic architecture of body weight and 11 body size traits at 120 days of age in 504 lion-head geese.

resultsSingle-SNP GWAS identified three major QTL regions located on Chr18: 2,436-6,745 kb (4,210 kb), Chr18: 9,756 - 10,076 kb (320 kb) and Chr25: 4,794-4,799 kb (5 kb), which were associated with body weight, semi-diving length, pelvic width, fossil bone length and chest depth. Genetic fine-mapping of these three QTL regions revealed 16 candidate genes and 68 important SNP-trait pairs. Out of these genes, MBTD1, CEP112, RAB11FIP4, APOH, and WIPI1 were associated with body weight and other body size traits. Among these SNP-trait pairs, we found a nonsynonymous mutation (c.C463A) in the MBTD1 influencing body weight and other two body size traits.

conclusionThese findings will enhance our understanding of the genetic architecture of body weight and body size traits at 120 days of age, which support the application of molecular breeding on these economically important traits in Lion-head geese.

Indexed as

Body SizeBody WeightChromosome MappingGeeseAnimalsGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideQuantitative Trait LociBody weight and body size traitsGenetic fine-mappingGWASLion-head geese

Identifiers

PMID40707914
PMCPMC12288364

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