Evidence map›Paper›PMID 40707827›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Objective measurement of cancer-related fatigue.

D M Beeler, C M O'Higgins, B Brady, D Walsh, R B Reilly

Abstract readReview
PubMed Publisher
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Cancer-related fatigue during treatment with neoadjuvant and/or adjuvant immune checkpoint inhibitors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Diagnostic predictive models for cancer-related fatigue: current evidence and future directions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

D M BeelerDepartment of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70331, Charlotte, NC, 28202, USA. dori.beeler@advocatehealth.org.
C M O'HigginsTrinity Centre for Biomedical Engineering, The University of Dublin, Dublin, Ireland.
B BradyOur Lady's Hospice and Care Services, Dublin, Ireland.
D WalshDepartment of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70331, Charlotte, NC, 28202, USA.
R B ReillyTrinity Centre for Biomedical Engineering, The University of Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis narrative review summarizes objective measures of cancer-related fatigue (CRF), their clinical and research utility, and their value in clinical practice and research. Objective measures are recommended where cognitive and physical CRF are the primary research outcomes of the studies reviewed.

methodsThis narrative review was done in two phases. The first, in 2018, evaluated CRF-focused studies published through peer review, and the second, from February 1, 2018, to March 31, 2024, included search results to identify more recent CRF articles. PubMed, Science Direct, and Scopus were used for the search. In both review phases, articles were excluded if they were abstracts only, editorials, or letters to the editor.

resultsThe literature searches resulted in 16,332 articles captured, 16,324 excluded, and 8 included. The review and analysis resulted in the discovery of 16 objective CRF assessments, categorized to correspond with their proposed CRF origin: central, peripheral, or both. Each assessment is described and outlined according to: (1) validated populations, (2) practicalities and clinical utility, and (3) applicability in the clinic space or bedside.

conclusionThis review is the foundation for objective CRF measurement. Recommendations include actigraphy, electrical muscle stimulation, finger tapping test, laboratory measures, positron emission tomography, and sit-to-stand in combination with subjective CRF measures to inform correlations, management, and treatment. An increase in objective measure pathophysiology research will illuminate the "black box" that is CRF.

Indexed as

FatigueNeoplasmsHumansCancerCancer-related fatigueCognitive fatigueFatigue measurementsPhysical fatigueSymptom

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.