Evidence map›Paper›PMID 40707786›Full record

ArticleMolecular psychiatry2025

5-HT

Matthew B Pomrenze, Sam Vaillancourt, Juliana S Salgado, Kendall B Raymond, Pierre Llorach, Hiroaki Sacai, Daniel Ryskamp Rijsketic, Tuuli M Hietamies, Gavin C Touponse, Daniel F Cardozo Pinto and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. αMolecular psychiatry · 2026
    Article
  2. Review
  3. Stereoselective, sex-dependent 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Matthew B PomrenzeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-9032-5911
Sam VaillancourtDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Juliana S SalgadoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-3687-846X
Kendall B RaymondNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Pierre LlorachDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Hiroaki SacaiDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Daniel Ryskamp RijsketicDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-2197-0730
Tuuli M HietamiesDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Gavin C TouponseDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-8087-3351
Daniel F Cardozo PintoNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-6104-4643
Zahra RastegarDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Austen B CaseyDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4670-851X
Neir EshelDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-5976-2013
Robert C Malenka *Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-5428-5211
Boris D Heifets *Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. bheifets@stanford.edu.ORCID http://orcid.org/0000-0003-1474-0379

Funding

Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Leanne Williams · 2017 to 2026
$27.1M
Mapping Neural Circuit Activity Mediating MDMA's Prosocial EffectR01MH130591 · NIMH · STANFORD UNIVERSITY · PI Boris Dov Heifets · 2023 to 2026
$2.3M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
Neural circuitry and synaptic physiology underlying MDMA's prosocial effectK08MH110610 · NIMH · STANFORD UNIVERSITY · PI HEIFETS, BORIS DOV · 2017 to 2020
$780k
Modulation of protracted opioid withdrawal by dorsal raphe dynorphin neuronsK99DA056573 · NIDA · STANFORD UNIVERSITY · PI POMRENZE, MATTHEW B · 2022 to 2023
$317k
NIDA NIH HHS K99 DA056573NIDA NIH HHS P50 DA042012NIMH NIH HHS K08 MH110610NIMH NIH HHS K08 MH123791NIMH NIH HHS R01 MH130591U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH110610U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH123791U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH130591U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA042012U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA056573
6 · The paper itself

Abstract

MDMA is a promising adjunct to psychotherapy and has well-known abuse liability, although less than other amphetamine analogs. While the reinforcing dopamine (DA)-releasing properties of MDMA are on par with methamphetamine (METH), MDMA is a far more potent serotonin (5-HT) releaser, via the 5-HT transporter (SERT). MDMA-mediated 5-HT release in a major reward center, the nucleus accumbens (NAc), drives prosocial behaviors via 5-HT

Indexed as

N-Methyl-3,4-methylenedioxyamphetamineNucleus AccumbensReceptor, Serotonin, 5-HT2CAnimalsDopamineMaleMethamphetamineMiceMice, Inbred C57BLMice, KnockoutRewardSerotoninSerotonin Plasma Membrane Transport ProteinsDopamineMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineReceptor, Serotonin, 5-HT2CSerotoninSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID40707786
PMCPMC12532699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.