Evidence map›Paper›PMID 40707781›Full record

ArticleBone marrow transplantation2025

Outcomes of hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia: a multicenter Brazilian cohort study.

Daniela Morales, Gisele Loth, Vergílio Antonio Rensi Colturato, Rita Barbosa Tavares, Simone Lermontov, Adriana Mello Rodrigues, Polliany Roberta Dorini Pelegrina, Cilmara Cristina Kuwahara, Nathalia Kersting, Ciliana Rechenmacher and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniela MoralesPrograma de Pós Graduação em Saúde da Criança e do Adolescente, Departamento de Pediatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0002-5518-1131
Gisele LothInstituto de Pesquisa Pelé Pequeno Príncipe/Hospital Pequeno Príncipe, Curitiba, Brazil.
Vergílio Antonio Rensi ColturatoHospital Amaral Carvalho, Jaú, São Paulo, Brazil.
Rita Barbosa TavaresInstituto Nacional do Câncer (INCA), Rio de Janeiro, Brazil.ORCID 0000-0002-9050-7918
Simone LermontovInstituto Nacional do Câncer (INCA), Rio de Janeiro, Brazil.
Adriana Mello RodriguesInstituto de Pesquisa Pelé Pequeno Príncipe/Hospital Pequeno Príncipe, Curitiba, Brazil.ORCID 0000-0002-1971-9299
Polliany Roberta Dorini PelegrinaInstituto de Pesquisa Pelé Pequeno Príncipe/Hospital Pequeno Príncipe, Curitiba, Brazil.
Cilmara Cristina KuwaharaInstituto de Pesquisa Pelé Pequeno Príncipe/Hospital Pequeno Príncipe, Curitiba, Brazil.
Nathalia KerstingLaboratório de Pediatria Translacional, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Ciliana RechenmacherLaboratório de Pediatria Translacional, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Priscila de Oliveira da SilvaHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Yasmine MonteiroLaboratório de Pediatria Translacional, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Mariana Bohns MichalowskiLaboratório de Pediatria Translacional, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-9482-0776
Mario Bernardes WagnerPrograma de Pós Graduação em Saúde da Criança e do Adolescente, Departamento de Pediatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Carmem BonfimInstituto de Pesquisa Pelé Pequeno Príncipe/Hospital Pequeno Príncipe, Curitiba, Brazil.
Liane Esteves DaudtPrograma de Pós Graduação em Saúde da Criança e do Adolescente, Departamento de Pediatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. ldaudt@hcpa.edu.br.ORCID 0000-0001-9495-6932

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute leukemias are prevalent among children and adolescents, with survival rates exceeding 90%, but high-risk cases often require hematopoietic stem cell transplantation (HSCT). Limited data are available on HSCT outcomes for pediatric acute lymphoblastic leukemia (ALL) in low- and middle-income countries. This Brazilian multicenter retrospective cohort study analyzed outcomes of ALL patients aged up to 18 years who underwent HSCT from January 2010 to June 2020. A total of 439 patients were included (69% male, 78.9% B-ALL). Unrelated donor transplants accounted for 49.9%, and haploidentical transplants for 18.9%. Bone marrow (82.6%) was the predominant stem cell source. Transplants occurred in the first or second complete remission (CR) in 38.7% and 44.2% of cases, respectively. The 100-day cumulative incidence of acute GvHD was 46.1%, and chronic GvHD after 100 days occurred in 25.5%. At five years, overall survival and event-free survival were 52.4% and 51.7%. By day +100, sepsis was the leading cause of mortality (42.3%), whereas relapse accounted for 76.3% of deaths thereafter. Findings align with HSCT literature, demonstrating similar outcomes despite challenges in developing countries and providing a basis for further research.

Indexed as

Hematopoietic Stem Cell TransplantationPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentBrazilChildChild, PreschoolCohort StudiesDisease-Free SurvivalFemaleGraft vs Host DiseaseHumansInfantMaleRetrospective StudiesSurvival RateTreatment Outcome

Identifiers

PMID40707781

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.