Evidence map›Paper›PMID 40707773›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2025

Prognostic impact of postoperative long-term skeletal muscle mass reduction after esophagectomy for esophageal cancer.

Daichi Utsunomiya, Yuto Kubo, Shotaro Horonushi, Ryoko Nozaki, Shota Igaue, Ryota Kakuta, Eigo Akimoto, Kentaro Kubo, Daisuke Kurita, Koshiro Ishiyama and 2 more

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daichi UtsunomiyaDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Yuto KuboDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Shotaro HoronushiDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Ryoko NozakiDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Shota IgaueDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Ryota KakutaDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Eigo AkimotoDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Kentaro KuboDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Daisuke KuritaDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Koshiro IshiyamaDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Junya OgumaDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Hiroyuki DaikoDepartment of Esophageal Surgery, National Cancer Center Hospital, 5-5-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan. hdaiko@ncc.go.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative low skeletal muscle mass (SMM) is a risk factor for poor prognosis in patients with esophageal cancer. However, the impact of long-term continuous SMM loss after esophagectomy on the prognosis of patients with esophageal cancer has been unclear. We aimed to evaluate whether long-term SMM loss after esophagectomy influences the prognosis of patients with esophageal cancer.

methodsThis study included 134 patients with esophageal cancer who underwent minimally invasive esophagectomy between October 2018 and October 2020. We retrospectively investigated the continuous decrease in skeletal muscle mass index (SMI) until 12 months after surgery and its relationship with recurrence. The patients were classified into three groups (short, middle, and long-term) by lowest SMI at 4, 8, and 12 months after surgery compared with preoperative SMI.

resultsThe overall survival did not differ significantly among the three groups. The long-term group was significantly associated with shortened recurrence-free survival (RFS) compared with the short-term and middle-term groups (3-year RFS rate, short-term group: 88.9% vs. middle-term group: 93.1% vs. long-term group: 72.5%, p = 0.043). The RFS was worse in the long-term SMM group than in middle-term SMM group (p = 0.072). The multivariate analysis identified the long-term group, Charlson Comorbidity Index ≧1, and pathological stage ≧ III, as independent factors associated with recurrence for patients with esophageal cancer.

conclusionsLong-term postoperative SMI reduction, as well as oncological factors, are significant predictors of late recurrence in patients with esophageal cancer.

Indexed as

Esophageal NeoplasmsEsophagectomyMuscle, SkeletalPostoperative ComplicationsSarcopeniaAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalPostoperative PeriodPrognosisRetrospective StudiesRisk FactorsEsophageal cancerEsophagectomyPrognosisSkeletal muscle

Identifiers

PMID40707773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.