Evidence map›Paper›PMID 40707750›Full record

ArticleDigestive diseases and sciences2025

Duodenal Villi Eosinophils: Association with Functional Dyspepsia Symptoms, but Not with Helicobacter pylori Infection.

Felipe Mazzoleni, Diego de Mendonça Uchoa, Luiz Edmundo Mazzoleni, Carlos Fernando de Magalhães Francesconi, Tobias Cancian Milbradt, Sacha Allebrandt da Silva Ries, Alexandra Cauduro Ponso Fernandes, Pedro Guilherme Schaefer, Liane Golbspan, Helenice Pankowski Breyer and 4 more

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Felipe MazzoleniPostgraduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. felipemazzoleni@hcpa.edu.br.
Diego de Mendonça UchoaDepartment of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Luiz Edmundo MazzoleniPostgraduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Carlos Fernando de Magalhães FrancesconiPostgraduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Tobias Cancian MilbradtPostgraduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Sacha Allebrandt da Silva RiesSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Alexandra Cauduro Ponso FernandesDepartment of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Pedro Guilherme SchaeferDepartment of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Liane GolbspanDepartment of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Helenice Pankowski BreyerDepartment of Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Matheus Truccolo MichalczukDepartment of Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Eduardo André OttDepartment of Gastroenterology, Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil.
Daniel SimonGraduate Program in Cellular and Molecular Biology, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Nicholas J TalleyFaculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDuodenal eosinophils have been associated with functional dyspepsia, but its association with Helicobacter pylori (H. pylori) remains unclear. Our aim was to investigate the connection between eosinophils in duodenal villi and dyspeptic symptoms, as well as its association with H. pylori infection.

methodsWe evaluated 100 functional dyspeptic patients, 50 H. pylori positive and 50 H. pylori negative, all meeting Rome III criteria. Participants underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies. Duodenal villi eosinophil were counted in 5 random high-power fields (HPF). We evaluated the association between duodenal villi eosinophils and dyspeptic symptoms using the validated PADYQ questionnaire. Duodenal villi eosinophils were also compared between H. pylori-positive and -negative groups and analyzed according to demographic and endoscopic variables.

resultsPatients were predominantly female (88%) with a mean age of 41.8 years. Median eosinophil/HPF in duodenal villi were 4.6 [2.8-7.2] in H. pylori negative and 4.7 [3.4-8.4] in H. pylori positive subjects (p = 0.40). Duodenal villi eosinophil increased with symptom severity: 3.4 [2.2-6.0] for mild, 4.7 [3.2-6.4] for moderate and 5.8 [3.6-8.2] for severe symptoms (p = 0.03). Multivariate analysis showed that duodenal villi eosinophils were independently associated with smoking (p = 0.02) and symptom severity (p = 0.04).

conclusionDuodenal villi eosinophils did not correlate with H. pylori infection but was associated with dyspepsia symptoms severity.

Indexed as

DuodenumDyspepsiaEosinophilsHelicobacter InfectionsHelicobacter pyloriAdultBiopsyFemaleHumansIntestinal MucosaMaleMiddle AgedDuodenal eosinophilsEosinophilsFunctional dyspepsiaH. pylori

Identifiers

PMID40707750

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