ReviewNature protocols2025
Printed photonic crystal biochips for rapid and sensitive detection of biomarkers in various body fluids.
Review in Nature protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Nanosensors in food safety detection: a comprehensive review of recent advances and future prospects.Mikrochimica acta · 2026Review
- Review
- Photonic Crystal Microarray-Assisted Point-of-Care Testing for Rapid and Convenient Detection of Microalbuminuria.ACS omega · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
There is an urgent requirement to improve accessibility to diagnostic tools in remote areas. This requires assays that are easy to use, are cost-effective and produce rapid results. Important public health applications include early disease diagnosis, real-time monitoring, epidemic control and medical cost control. This protocol describes the fabrication of all-printed photonic crystal (PC) biochips for point-of-care testing of biomarkers. The photonic crystal material is prepared by the self-assembly of latex nanospheres that are printed onto a polyethylene terephthalate substrate. Photonic crystals composed of latex nanospheres of different sizes enhance the fluorescent signal emitted at different wavelengths, resulting in remarkably higher detection sensitivity. PC microarrays enable mass-printed preparation (up to 2,700 pieces can be printed per hour by one printer), and each microarray can be stored for a long time (>6 months) after heating. Biomarker specificity is achieved by the biofunctionalization of the nanospheres, for example, attaching capture antibodies. The detection involves the use of a fluorescently labeled detection antibody and a simple point-of-care detection device. This universal approach can be applied to the detection of many biomarkers, and the simultaneous detection of multiple biomarkers is also possible. Here we demonstrate describing how to prepare a chip that can be used to detect three inflammatory biomarkers in 10 min at low sample volumes at a cost of less than 3 CNY (~US$0.41) per PC codetection biochip. The biofunctionalization process including capture antibody coupling and blocking takes 3-4 h, and the detection process takes 20 min.
Indexed as
Identifiers
40707741What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.