ArticleBJC reports2025
Circulating tumor DNA monitoring detects minimal residual disease and predicts outcomes in patients with esophageal adenocarcinoma or squamous cell carcinoma after esophagectomy.
Article in BJC reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Circulating Tumor DNA for Minimal Residual Disease Detection and Recurrence Prediction in Upper Gastrointestinal Cancers: A Scoping Review.Journal of clinical medicine · 2026Review
- The role of the WD40-repeat protein family in cancer.Molecular cancer · 2026Review
- Practical integration of ctDNA-defined minimal residual disease in gastrointestinal cancers: testing windows and evidence-aligned management frameworks.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- [Clinical strategies for perioperative management of esophageal squamous cell carcinoma in the immunotherapy era].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Review
- Review
- Rethinking biomarker strategy in gastric cancer immunotherapy: from tumor to host.Frontiers in immunology · 2026Review
- Application of a modified MSRE-qPCR method for detecting circulating cell-free DNA methylation in cervical cancer.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundCirculating tumor DNA (ctDNA) monitoring shows promise for detecting minimal residual disease (MRD) and predicting prognosis in various cancers, but its role in esophageal cancer (EC) post-esophagectomy is unclear. This study evaluated ctDNA for detecting MRD and predicting outcomes in EC patients.
methodsA two-step observational study included 40 EC patients (36 squamous cell carcinoma and 4 adenocarcinoma) undergoing upfront surgery or neoadjuvant chemotherapy (NAC) followed by esophagectomy. Plasma samples (n = 124) were collected at six time points, and ctDNA was assessed by next-generation sequencing using an in-house cancer panel. Associations with clinical outcomes were analyzed.
resultsPre-therapy ctDNA levels correlated with tumor stage (P = 0.01). Changes in ctDNA levels predicted tumor progression with an area under the curve of 0.77. Postsurgical ctDNA positivity predicted recurrence earlier than radiographic evidence (median: 90 days) and was associated with shorter recurrence-free survival (RFS) and progression-free survival (PFS) across all patients (RFS hazard ratio [HR]: 11.1, P = 0.006; PFS HR: 12.6, P = 0.002).
conclusionsctDNA assessment is a reliable tool for detecting MRD and predicting outcomes in EC patients after esophagectomy. This approach provides earlier indications of recurrence and can guide personalized postoperative management.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.