ArticleAnnals of hematology2025
Semen quality in acute leukemia patients: a retrospective study.
Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effects of Cytotoxic Therapies on the Sperm Genome and Epigenome.Advances in experimental medicine and biology · 2026Review
- Semen Quality in Patients with Hematological Malignancies: A Retrospective Monocentric Study in the Perspective of Personalized Oncofertility Medicine.Journal of personalized medicine · 2025Article
- Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men.Current issues in molecular biology · 2025Review
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the cancer types that commonly affect men of reproductive age there are leukemias. In literature, little is known about the correlation between semen quality and acute leukemia. It could be assumed that the disease may evoke a systemic response mediated by cytokines secreted by tumor cells, which may have an impact on semen parameters. Significant advances in survival rates due to new therapeutic strategies have focused attention on fatherhood and fertility preservation. The aim of this study was to evaluate semen quality of patients with acute leukemia before chemotherapy. We also evaluated semen parameters after therapy in a subgroup of patients and we collected fertility information. Finally, we collected information about the feasibility of the semen cryopreservation and evaluated any shifts in the approach to fertility preservation in these patients. A retrospective study was conducted, and it included the collection of data related to: semen analysis, information related to paternity desire and childbearing, number of cryopreservations performed over the years and the feasibility of the procedure. The median semen characteristics of these patients were above the 25° percentile, before cancer treatment. After therapies, an increase of the percentage of azoospermic at one year of follow-up can be observed. Four patients succeeded in achieving fatherhood through at least one cycle of assisted reproductive technology. These results allow us to recommend increased awareness among onco-hematologists about cryopreservation of semen for acute leukemia patients to ensure that they can become parents in the future and face the treatment course with greater confidence.
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