Children identified for classroom-based math support show altered resting-state connectivity in parietal brain regions.

Isabella Starling-Alves, Lina Shanley, Madison A Cook, Fred W Sabb, Jolinda Smith, Ben Clarke, Eric D Wilkey

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Isabella Starling-AlvesDepartment of Psychology & Human Development, Peabody College, Vanderbilt University, Nashville, TN, USA.

Lina ShanleyCenter on Teaching and Learning, University of Oregon, Eugene, OR, USA.

Madison A CookCenter on Teaching and Learning, University of Oregon, Eugene, OR, USA.

Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR, USA.

Jolinda SmithRobert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA.

Ben ClarkeCenter on Teaching and Learning, University of Oregon, Eugene, OR, USA.

Eric D WilkeyDepartment of Psychology & Human Development, Peabody College, Vanderbilt University, Nashville, TN, USA. eric.d.wilkey@vanderbilt.edu.

Funding

Division of Research on Learning in Formal and Informal Settings 1660840National Center for Special Education Research, Institute of Education Sciences R324A160046

6 · The paper itself

Abstract

Approximately 25% of school-age children experience mathematics difficulties (MD). Mathematics skills have been correlated with resting-state functional connectivity (rsFC) between parietal brain regions, including the intraparietal sulcus (IPS) and the angular gyrus (AG), and a fronto-parietal network. However, the patterns of rsFC in children with MD remain less clear. This study conducted a seed-to-voxel analysis contrasting the rsFC profiles of 46 1st graders with MD (mean age = 6.95, sd = 0.34) and 60 1st graders with typical achievement (mean age = 7.08, sd = 0.38) in subdivisions of the intraparietal sulcus (hIP1, hIP2, and hIP3) and the angular gyrus (PGa, and PGp), bilaterally. Results suggested a pattern of hyperconnectivity between the right hIP2 and the left hippocampus and hypoconnectivity between the right PGa and the right ventral occipito-temporal cortex in children with MD. A multivariate classification analysis based on the rsFC maps extracted from the IPS and AG subdivisions indicated that a support-vector machine classifier distinguished between groups with accuracy above chance, particularly based on the rsFC of the left hIP1, the right hIP3, and the left PGp. These findings suggest atypical rsFC in the IPS and the AG in MD, with patterns of both hyper- and hypoconnectivity.

Indexed as

MathematicsParietal LobeBrain MappingChildConnectomeFemaleHumansMagnetic Resonance ImagingMaleNerve NetAngular gyrusDyscalculiaIntraparietal sulcusLearning disorderResting-state functional connectivity

Identifiers

PMID40707592

DOI10.1038/s41598-025-12809-7

PMCPMC12290048

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.