Evidence map›Paper›PMID 40707490›Full record

ArticleScientific reports2025

Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear.

Franziska Labrenz, Anne Kalenbach, Sigrid Elsenbruch, Adriane Icenhour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Franziska LabrenzDepartment of Medical Psychology and Medical Sociology, Ruhr University Bochum, Bochum, Germany.
Anne KalenbachDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Duisburg-Essen, Germany.
Sigrid ElsenbruchDepartment of Medical Psychology and Medical Sociology, Ruhr University Bochum, Bochum, Germany.
Adriane IcenhourDepartment of Affective Neuroscience, Ruhr University Bochum, Universitaetsstrasse 105, 44789, Bochum, Germany. adriane.icenhour@ruhr-uni-bochum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Along the gut-brain axis, visceral pain demonstrably evokes emotional learning and memory processes shaping behavior in clinically relevant ways. Avoidance motivated by learned fear may constitute a major obstacle to treatment success in extinction-based interventions. However, the effects of avoidance on visceral pain-related fear extinction remain poorly understood. By implementing an ecologically valid experimental protocol, we investigated how costly avoidance affects the modulation and extinction of visceral pain-related fear. Thirty-three healthy volunteers underwent conditioning with visual cues (conditioned stimuli; CS

Indexed as

Avoidance LearningExtinction, PsychologicalFearVisceral PainAdultConditioning, ClassicalCuesFemaleHealthy VolunteersHumansMaleYoung AdultAvoidanceExtinctionFear conditioningGut-brain axisPain-related fearVisceral pain

Identifiers

PMID40707490
PMCPMC12289990

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.