Evidence map›Paper›PMID 40707421›Full record

ArticleCancer science2025

Proposal for a Germline Expert Panel to Improve Variant Reclassification in Japan.

Kazuki Yamazawa

Abstract readLetter
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comprehensive evidence for the pathogenicity of theJournal of medical genetics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kazuki YamazawaDepartment of Medical Genetics, NHO Tokyo Medical Center, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4895-2759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This letter argues that Japan's dependence on a single foreign company for classifying germline variants is delaying critical treatment for cancer patients. The author proposes establishing a national "Germline Expert Panel" to provide independent, timely oversight, and ensure patients receive appropriate care.

Indexed as

Genetic TestingGerm-Line MutationNeoplasmsGenetic Predisposition to DiseaseHumansJapan

Identifiers

PMID40707421
PMCPMC12485658

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.