ReviewAnnals of medicine2025
Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?International journal of molecular sciences · 2026Review
- Extracellular vesicle-mediated bidirectional communication between the brain and peripheral organs in Alzheimer's disease: evidence, mechanisms, and translational perspectives.Journal of nanobiotechnology · 2026Review
- Article
- Harnessing the Therapeutic Potential of Extracellular Vesicles for Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-healing wounds lead to tissue dysfunction, contributing to pathological conditions and compromising overall health. Recently, microRNAs have been shown to regulate diverse biological events, including cell migration, proliferation, angiogenesis, scar formation, and wound closure. Interestingly, cells selectively sort microRNAs into extracellular vesicles, which can be up-taken by cells to regulate the healing process. Consequently, extracellular vesicles and their microRNA content serve as an AIMS AND
methodsThis review aims to explore the association between microRNAs and the wound healing process, and the roles of extracellular vesicle-derived miRNAs in different cell populations within the wound microenvironment. We searched PubMed, Web of Science, and Scopus using the keywords: exosomes, mesenchymal stem cell-derived exosomes, wound healing, and microRNA. Relevant data were collected and summarized.
resultsThis review provided information about extracellular vesicles, microRNA biogenesis, and their roles in wound healing. Results highlighted the roles of extracellular vesicle-derived microRNAs in anti-inflammatory responses, promoting cell migration, proliferation, and differentiation while inhibiting apoptosis during wound repair. Beyond their natural functions, extracellular vesicles and their microRNA cargoes hold significant potential for therapeutic and diagnostic applications in wound healing. We also outlined the potential use of extracellular vesicle-derived microRNAs as drug delivery systems and miRNA-based monitoring tools.
conclusionExtracellular vesicle-derived microRNAs play important roles in wound healing. Despite their promise, challenges such as lack of standardization in isolation, precise delivery, and reliable quantification methods remain obstacles for clinical implementation in disease diagnosis and prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.