Evidence map›Paper›PMID 40707360›Full record

ArticleGenes & development2025

Lineage rewiring in lung adenocarcinoma via HNF4α and NKX2-1 dynamics.

Alice Feng, Alena Yermalovich, Matthew Meyerson

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alice FengDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Alena YermalovichDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Matthew MeyersonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; matthew_meyerson@dfci.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lineage plasticity drives treatment resistance in lung adenocarcinoma (LUAD) as cancer cells adopt new identities. In this issue of

Indexed as

Adenocarcinoma of LungCell LineageHepatocyte Nuclear Factor 4Lung NeoplasmsThyroid Nuclear Factor 1AnimalsGene Expression Regulation, NeoplasticHumansMiceHepatocyte Nuclear Factor 4NKX2-1 protein, humanNkx2-1 protein, mouseThyroid Nuclear Factor 1hybrid identityKRAS inhibitionlineage plasticitylineage specifierslung adenocarcinoma

Identifiers

PMID40707360
PMCPMC12404191

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.