ArticleInternal medicine (Tokyo, Japan)2026
Intrathoracic Rhabdoid Tumors Showing Rapid Progress in Patients with a History of Immune-suppressive Therapies for Hematological Diseases.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We herein report 2 autopsied cases of intrathoracic undifferentiated/rhabdoid neoplasms showing rapid progress in patients who received immunosuppressive therapies for hematological diseases (Case 1, a 72-year-old man who underwent hematological cell transplantation for aplastic anemia; Case 2, a 77-year-old man who received chemotherapy for multiple myeloma). Both patients experienced progressive pulmonary effusion and died after three months and two weeks of follow-up, respectively. Autopsy revealed rhabdoid neoplasms infiltrating the alveolar spaces in both cases. Nuclear immunoreactivity for SMARCB1/INI1 was lost in Case 2. Clinicians and pathologists should consider the possibility of rapidly progressive neoplasms, such as intrathoracic undifferentiated/rhabdoid neoplasm, as a differential diagnosis for pneumonia in possible immunosuppressive conditions.
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