ArticleBMJ open2025
Effect of obstructive sleep apnoea syndrome combined with renal insufficiency on all-cause mortality in elderly patients in China: a prospective cohort study.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveWe hypothesised that all-cause mortality in elderly patients with obstructive sleep apnoea syndrome (OSAS) was associated with renal insufficiency.
designA cohort study.
settingA prospective study of patients with OSAS enrolled in sleep centres/departments in multicentre hospitals in China from 2015 to 2017.
participantsA total of 1290 patients with OSAS from six tertiary comprehensive hospitals in China were included in this study; of these, 1076 patients were included in the analysis based on inclusion and exclusion criteria.
main outcome measuresAll-cause death events were the main adverse outcomes.
resultDuring a median follow-up of 42 months, 50 patients (4.6%) died, including 24 (2.2%) cardiovascular deaths. The incidence of all-cause death and cardiovascular death was higher in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m
conclusionThe incidence of all-cause death and cardiovascular death events increased with decreasing renal function in elderly patients with OSAS and was higher in patients with end-stage renal insufficiency. The risk of all-cause and cardiovascular deaths was highest at eGFR below 30 mL/min/1.73 m
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