Evidence map›Paper›PMID 40707146›Full record

SynthesisBMJ open2025

Effect of nature-based health interventions for individuals diagnosed with anxiety, depression and/or experiencing stress-a systematic review and meta-analysis.

Nanna Holt Jessen, Claus Løvschall, Sebastian Dyrup Skejø, Louise Sofia Sofia Madsen, Sus Sola Corazon, Thomas Maribo, Dorthe Varning Poulsen

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Connected by Nature: Nature-Based Intervention to Support Young Adults with Advanced Cancer.International journal of environmental research and public health · 2026
    Article
  5. Article
  6. Article
  7. Review
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nanna Holt JessenResearch Unit for General Practice, Aarhus, Aarhus, Denmark n.holt@ph.au.dk.ORCID http://orcid.org/0000-0002-2032-1691
Claus LøvschallDEFACTUM, Central Denmark Region, Denmark, Aarhus, Denmark.
Sebastian Dyrup SkejøResearch Unit for General Practice, Aarhus, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-8878-0205
Louise Sofia Sofia MadsenDEFACTUM, Central Denmark Region, Denmark, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0919-2454
Sus Sola CorazonDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Copenhagen, Denmark.
Thomas MariboDEFACTUM, Central Denmark Region, Denmark, Aarhus, Denmark.
Dorthe Varning PoulsenDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe use of natural environments and nature activities as elements in the treatment and rehabilitation of mental health challenges is gaining international attention. The objective of the present review was to summarise the knowledge on the effects of nature-based health interventions (NBHIs) targeting individuals diagnosed with anxiety, depression and/or experiencing stress.

designSystematic review and meta-analyses. The quality and certainty of evidence were assessed using the SIGN and GRADE. DATA SOURCES: Searches were performed in Embase, MEDLINE, PsycINFO, CINAHL, Cochrane and Web of Science. ELIGIBILITY CRITERIA: (1) NBHIs, (2) Individuals with a diagnosis of mild to moderate anxiety, depression and/or experiencing stress, (3) Age of participating individuals: 18-84 years, (4) Study designs: randomised controlled trials, cohort studies, case-control studies and case-series studies and (5) Publication date: 2000-2024. DATA EXTRACTION AND SYNTHESIS: Screening, quality appraisal and certainty of evidence, assessed using SIGN and GRADE, were performed by two independent reviewers, except title screening. Meta-analyses were performed using random-effect models.

resultsNineteen articles were included, of which 14 were included in the meta-analyses. The articles showed substantial variation in design, interventions, settings and risk of bias, limiting the certainty of evidence according to GRADE. Participating in NBHIs led to a small to large effect in mental health with standardised mean changes of -0.80 (95% CI= (-1.56; -0.04)), -0.87 (95% CI= (-1.18; -0.56)), -0.32 (95% CI= (-0.74; 0.09)) and 0.58 (95% CI= (0.39; 0.77)) for anxiety, depression and stress scores and overall mental health scores, respectively.

conclusionsThis is the first systematic review examining the effect of NBHIs exclusively on individuals diagnosed with anxiety, depression and/or experiencing stress. Our findings suggest small to large improvements after participating in NBHIs. However, methodological limitations to the included articles necessitate cautious interpretation. PROSPERO REGISTRATION NUMBER: CRD42024516270.

Indexed as

AnxietyDepressionNatureStress, PsychologicalHumansAnxiety disordersDepression & mood disordersPsychological Stress

Identifiers

PMID40707146
PMCPMC12306343

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.