Evidence map›Paper›PMID 40707131›Full record

ArticleJournal for immunotherapy of cancer2025

Specific inhibitor to KRAS

Zhi Zhu, Hongqi Chen, Chao Feng, Lingjuan Chen, Congrong Ma, Zuqiang Liu, Zhaoxia Qu, David L Bartlett, Binfeng Lu, Kai Li and 1 more

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhi Zhu *Department of Surgical Oncology, the First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Hongqi Chen *Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Chao FengUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Lingjuan ChenDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID http://orcid.org/0000-0003-2463-0640
Congrong MaDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zuqiang LiuDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID http://orcid.org/0009-0007-0581-3528
Zhaoxia QuUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
David L BartlettDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Binfeng LuUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-7822-5950
Kai LiDepartment of Surgical Oncology, the First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China Guozs2007@gmail.com cmu_likai@163.com.
Zong Sheng GuoDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Guozs2007@gmail.com cmu_likai@163.com.ORCID http://orcid.org/0000-0002-4624-9907

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Exploring IL-36gamma as a new tumor immune therapyR21CA205727 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LU, BINFENG · 2016 to 2017
$370k
NCI NIH HHS P30 CA047904NCI NIH HHS R21 CA205727
6 · The paper itself

Abstract

backgroundOncolytic virus (OV)-mediated immunotherapy has been shown limited efficacy. Small molecule inhibitors specific to the KRAS

methodsWe explored combination therapies using KRAS

resultsWe confirmed that three inhibitors for KRAS

conclusionsSmall molecule inhibitors of KRAS

Indexed as

ImmunotherapyOncolytic VirotherapyOncolytic VirusesProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorFemaleHumansMiceKRAS protein, humanProto-Oncogene Proteins p21(ras)Immune Checkpoint InhibitorImmunotherapyLung CancerOncolytic virusT-Lymphocytes

Identifiers

PMID40707131
PMCPMC12306217

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.