Evidence map›Paper›PMID 40707058›Full record

ReviewJournal of obesity & metabolic syndrome2025

Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.

Yu Fu

Abstract readReview
In one paragraph

Review in Journal of obesity & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Yu FuDivision of Neurometabolism, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.ORCID https://orcid.org/0000-0002-9226-1982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptide and pro-opiomelanocortin neurons have been discovered to play critical roles in feeding and body weight regulation. Recent studies have started to reveal the functional significance of other neuronal populations, especially those that promote feeding (orexigenic neurons). In this review, we discuss the history and key findings of the arcuate nucleus, with a focus on orexigenic neurons. We also highlight current challenges and knowledge gaps that remain to be addressed in future studies.

Indexed as

Agouti related neuropeptideArcuateBody weightFeedingHypothalamus

Identifiers

PMID40707058
PMCPMC12318705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.