Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Memet T EminPediatric Critical Care, Hospitalist, and Palliative Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, United States.
Alexandra M DubuissonPediatric Critical Care, Hospitalist, and Palliative Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, United States.ORCID 0009-0001-0108-108X
Prisha Sujin KumarPediatric Critical Care, Hospitalist, and Palliative Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, United States.
Carsten KnutsenDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, California, United States.
Cristina M AlviraDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, California, United States.ORCID 0000-0002-6921-0001
Rebecca F HoughPediatric Critical Care, Hospitalist, and Palliative Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, United States.ORCID 0000-0002-0203-4146
Funding
Developmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell ResolutionR01HL154002 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVIRA, CRISTINA MARIA · 2021 to 2024
$2.8M
Diverse Homeostatic Roles for Distinct Macrophages in the Developing Lung VasculatureR01HL155828 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVIRA, CRISTINA MARIA · 2021 to 2024
$2.6M
Mitochondrial mechanisms underlying alveolar-capillary barrier regulationK08HL148403 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOUGH, REBECCA FRANCES · 2020 to 2024
$827k
Columbia University Department of Pediatrics Innovation Nucleation FundHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL148403NHLBI NIH HHS K08 HL148403NHLBI NIH HHS R01 HL154002NHLBI NIH HHS R01 HL155828Stony Wold-Herbert Fund (The Stony Wold-Herbert Fund) Grant-in-aid
6 · The paper itself
Abstract
Acute lung injury (ALI) causes the highly lethal acute respiratory distress syndrome (ARDS) in children and adults, for which therapy is lacking. Children with pediatric ARDS have a mortality rate that is about half of adults with ARDS. Improved ALI measures can be reproduced in rodent models with juvenile animals, suggesting that physiologic differences may underlie these outcomes. Here, we show that pneumonia-induced ALI caused inflammatory signaling in the endothelium of adult mice, which depended on Yes-associated protein (YAP). This signaling was not present in 21-day-old weanling mice. Transcriptomic analysis of lung endothelial responses revealed nuclear factor-kappa B (NF-κB) as significantly increased with ALI in adult versus weanling mice. Blockade of YAP signaling protected against inflammatory response, hypoxemia, and NF-κB nuclear translocation in response to
Indexed as
Acute Lung InjuryAdaptor Proteins, Signal TransducingAgingInflammationLungSignal TransductionAge FactorsAnimalsEndotheliumHumansMaleMiceMice, Inbred C57BLNF-kappa BPneumoniaPseudomonas aeruginosaAdaptor Proteins, Signal TransducingNF-kappa BYap1 protein, mouseYAP-Signaling Proteinsacute lung injurylung endotheliumNF-κBPARDSYes-associated protein
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium. · full record | OpenQuestion