Evidence map›Paper›PMID 40707007›Full record

ArticleACS infectious diseases2025

Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides.

Ruo-Lan Du, Cheung-Hin Hung, Alan Siu-Lun Leung, Kang Ding, Wai-Po Kong, Yong Wang, Zhi-Guang Liang, Pak-Ho Chan, Kwok-Yin Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruo-Lan DuDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Cheung-Hin HungDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.ORCID 0000-0003-2610-2630
Alan Siu-Lun LeungDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Kang DingDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Wai-Po KongDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.ORCID 0000-0002-7245-5149
Yong WangDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.ORCID 0000-0002-1292-0459
Zhi-Guang LiangDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Pak-Ho ChanDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Kwok-Yin WongDepartment of Applied Biology and Chemical Technology (ABCT), The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.ORCID 0000-0003-4984-7109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid increase in bacterial resistance to conventional antibiotics has led to a great demand for novel antibacterial agents. Antimicrobial peptides (AMPs) are emerging as next-generation antimicrobial alternative drugs to conventional antibiotics because of their broad-spectrum antimicrobial activities and minimal potential for drug resistance induction. This work describes novel antimicrobial peptides (FtsZpcpp) synthesized through the conjugation of a cell penetration peptide ((RXR)

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesBacterial ProteinsCell-Penetrating PeptidesCytoskeletal ProteinsErythrocytesGram-Negative BacteriaGram-Positive BacteriaHemolysisHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesBacterial ProteinsCell-Penetrating PeptidesCytoskeletal ProteinsFtsZ protein, Bacteriaantibiofilmantimicrobial peptidesantimicrobial resistancecell divisioncell membranecell penetrating peptide

Identifiers

PMID40707007
PMCPMC12340945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.