Evidence map›Paper›PMID 40706632›Full record

ArticleCancer science2025

Single-Cell Transcription Reveals the Fibroblast Heterogeneity and Neural Cells' Significance in Desmoid Fibromatosis.

Junfeng Wang, Cheng Zhou, Peng Huang, Haodong Li, Ping Xu, Yiming Zheng, Dahui Wang, Bo Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junfeng WangDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Cheng ZhouDepartment of Orthopedics, Anhui Provincial Children's Hospital Affiliated to Anhui Medical University, and The Fifth Clinical Medical College of Anhui Medical University, Hefei, P.R. China.
Peng HuangDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Haodong LiDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Ping XuDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Yiming ZhengDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Dahui WangDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.
Bo NingDepartment of Orthopedics, Children's Hospital of Fudan University, Shanghai, P.R. China.ORCID https://orcid.org/0000-0002-9752-2459

Funding

National Natural Science Foundation of China 82272441Science and Technology Commission of Shanghai Municipality 22Y11912200
6 · The paper itself

Abstract

Desmoid fibromatosis (DF) is a refractory tumor with a high recurrence rate, resulting in severe organ's deformity, morbidity, and mortality. The cellular characteristics of DF remain elusive. Herein, we performed single-cell RNA sequencing (scRNA-seq) to reveal the cell landscape of DF. To uncover the exclusive characteristics of DF, we compared the transcriptional profile of DF with that of keloid fibroblast (KF) and normal fibroblast (NF) in the public data (GSE163973). When compared with KF and NF, mesenchymal fibroblasts were significantly expanded in DF. The mesenchymal fibroblasts were further divided into two subtypes according to the differentiation states, among which LAMP5

Indexed as

Desmoid TumorsFibroblastsSingle-Cell AnalysisCyclic AMP Response Element-Binding ProteinGene Expression ProfilingHumansNerve Tissue ProteinsTumor MicroenvironmentCREB3L1 protein, humanCyclic AMP Response Element-Binding ProteinNerve Tissue Proteinschildrendesmoid fibromatosisfibroblastneural cellsingle‐cell RNA sequencing

Identifiers

PMID40706632
PMCPMC12485654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.