Evidence map›Paper›PMID 40706598›Full record

ArticleMolecular cell2025

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Lixin Wan, Kexin Xu, Yongkun Wei, Jinfang Zhang, Tao Han, Christopher Fry, Zhao Zhang, Yao Vickie Wang, Liyu Huang, Min Yuan and 17 more

Abstract readPublished Erratum
In one paragraph

Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Post-translational modifications in CD8Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Lixin Wan
Kexin Xu
Yongkun Wei
Jinfang Zhang
Tao Han
Christopher Fry
Zhao Zhang
Yao Vickie Wang
Liyu Huang
Min Yuan
Weiya Xia
Wei-Chao Chang
Wen-Chien Huang
Chien-Liang Liu
Yuan-Ching Chang
Jinsong Liu
Yun Wu
Victor X Jin
Xiangpeng Dai
Jianfeng Guo
Jia Liu
Shulong Jiang
Jin Li
John M Asara
Myles Brown
Mien-Chie Hung
Wenyi Wei

Funding

Use of Organotypic and Mammary Gland Models to Investigate the Outcomes of ClonalP01CA080111 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DILLON, DEBORAH · 1999 to 2018
$36.0M
Novel regulation of PI3K/Akt to direct targeted breast cancer therapiesR01CA177910 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2013 to 2023
$3.9M
Interplay between Cdh1 and major regulatory pathways in human cancerR01GM089763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2009 to 2018
$3.0M
Omics analysis of three-dimensional transcriptional regulationR01GM114142 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIN, VICTOR, LIN, SHILI · 2015 to 2024
$2.7M
Rational Combination Therapy with PARP Inhibitors in Triple Negative Breast CancerR01CA211615 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YANG, LIUQING · 2017 to 2021
$2.1M
Functional analysis of beta-TRCP in cell cycle control and DNA damage responseR01GM094777 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2012 to 2015
$1.3M
Function of the METTL3-NUP93 complex-mediated nuclear export of m6A-modified mRNAs in castration-resistant prostate cancer.R01CA279681 · NCI · UNIVERSITY OF VIRGINIA · PI Kexin Xu · 2024 to 2026
$1.3M
A Novel Oncogenic Role for Cdc20 Implications in Adult T Cell Leukemia TreatmentR00CA183914 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI WAN, LIXIN · 2016 to 2018
$652k
Polycomb -Independent Functions of EZH2 in Castration Resistant Prostate CancerR00CA178199 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, KEXIN · 2015 to 2017
$498k
Elucidating a Novel Mechanism for SPOP in Suppressing Prostate TumorigenesisK99CA212292 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZHANG, JINFANG · 2017 to 2018
$338k
NCI NIH HHS K99 CA212292NCI NIH HHS P01 CA080111NCI NIH HHS R00 CA178199NCI NIH HHS R00 CA183914NCI NIH HHS R01 CA177910NCI NIH HHS R01 CA211615NCI NIH HHS R01 CA279681NIGMS NIH HHS R01 GM089763NIGMS NIH HHS R01 GM094777NIGMS NIH HHS R01 GM114142
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40706598
PMCPMC12362043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.