ArticleParkinsonism & related disorders2025
Cause of death for patients who present with primary progressive apraxia of speech.
Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundApraxia of speech (AOS) can be the initial and sole manifestation of neurodegenerative diseases, termed primary progressive apraxia of speech (PPAOS). These patients frequently evolve to atypical parkinsonism. There is little information to inform end of life planning and expectations.
objectiveThis study explored causes of death in patients who presented with PPAOS.
methodsData for 29 deceased PPAOS patients and for whom cause of death data were available were reviewed.
resultsMedian age at death was 76.25 years following a median disease duration of 9.78 years. Fifteen patients (52 %) succumbed to deterioration from the disease, ten (34 %) died from complications associated with dysphagia, and the remainder from a brain bleed associated with a fall (10 %) or medical aid in dying (3 %).
conclusionsThe findings inform counseling and underscore the need for comprehensive, interdisciplinary care addressing swallowing impairments and systemic disease to prevent or delay causes of death.
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