Transcription-coupled repair of crosslinking DNA damage.

Rebecca Roddan, Lucy R Henderson, Malitha Ratnaweera, Peter J McHugh

Abstract readReview

In one paragraph

Review in DNA repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.Research square · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebecca RoddanDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

Lucy R HendersonDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

Malitha RatnaweeraDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

Peter J McHughDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address: peter.mchugh@imm.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impediments to faithful transcription must be resolved to ensure accurate gene expression and safeguard normal cellular function. Dedicated DNA repair pathways have therefore evolved to remove transcription-blocking DNA damage, targeted to active genes. Although significant research efforts to date have focussed on the transcription-coupled repair of bulky, UV-induced DNA damage, it is known that other forms of DNA damage can perturb RNA Polymerase II progression. Only in recent years has insight into these pathways emerged, despite the clinical significance of understanding all transcription-coupled repair pathways. These recent observations have highlighted substantial molecular differences in these pathways compared to the canonical UV-damage repair mechanisms. This review summarises our understanding to date of the molecular mechanisms that act to remove both DNA-DNA and DNA-protein crosslinks that block transcription in mammalian cells.

Indexed as

DNADNA DamageDNA RepairTranscription, GeneticAnimalsExcision RepairHumansRNA Polymerase IIUltraviolet RaysDNARNA Polymerase IIDNA crosslinksDNA protein crosslinksExcision repairInterstrand crosslinks

Identifiers

PMID40706399

DOI10.1016/j.dnarep.2025.103869

PMCPMC7618990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.