Evidence map›Paper›PMID 40706328›Full record

ArticleJournal of psychosomatic research2025

Characterization of psychiatric admissions in Huntington disease: A retrospective review.

Shuhei Shiino, Sarah Moroz, Jeffrey Stovall, William M Petrie, Daniel O Claassen, Katherine E McDonell

Abstract read
In one paragraph

Article in Journal of psychosomatic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Psychosis in Huntington disease: a short update.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuhei ShiinoDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah MorozETSU Quillen College of Medicine, Johnson City, TN, USA. Electronic address: morozs@etsu.edu.
Jeffrey StovallDepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: jeffrey.stovall@vumc.org.
William M PetrieDepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: william.petrie@vumc.org.
Daniel O ClaassenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: daniel.claassen@vumc.org.
Katherine E McDonellDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: katherine.mcdonell@vumc.org.

Funding

Inhibitory Control and Externalizing Behaviors in Youth at Risk for Huntington DiseaseK23NS126628 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Katherine McDonell · 2022 to 2026
$884k
NINDS NIH HHS K23 NS126628
6 · The paper itself

Abstract

objectiveNeuropsychiatric symptoms are common clinical features of Huntington disease (HD) that can result in mental health emergencies. However, there are no established guidelines for inpatient psychiatric treatment in HD. In this study, the investigators reviewed psychiatric hospitalizations in a large medical center to better understand the mental health needs of patients with HD and identify potential gaps in care.

methodsCharts were reviewed to identify patients with HD at Vanderbilt University Medical Center who were admitted to psychiatry between 2013 and 2020. Clinical data and demographic information were obtained from the electrical health record along with the indication for each psychiatric admission, actions taken during the admission, and follow-up care.

resultsAmong this cohort, 32 of 287 patients (11.1 %) were admitted to inpatient psychiatry at least once. Age at first admission ranged from 17 to 74 years, with 84.4 % of patients in the motor-manifest stage. The most common reasons for admission were suicidal ideation or attempt (57.6 %), psychosis (39.4 %), and aggression (36.4 %). Most patients were able to return to their previous level of care, although readmissions were common.

conclusionsThese results emphasize the frequency and severity of psychiatric crises in HD and support the need for expanded access to emergency psychiatry care across the disease course. Further research is warranted to develop an integrated, disease-specific approach to early recognition and management of psychiatric symptoms in HD.

Indexed as

AggressionHospitalizationHuntington DiseaseMental DisordersPsychotic DisordersSuicidal IdeationAdolescentAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSuicide, AttemptedYoung AdultBehaviorHuntington diseaseInpatientNeuropsychiatricPsychiatry

Identifiers

PMID40706328
PMCPMC13225137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.