ArticleInorganic chemistry2025
Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts.
Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Beyond Histone Demethylation: Mechanisms ofJACS Au · 2026Article
- Mutagenicity and Repair of Acrolein Adduct to Cytosine.International journal of molecular sciences · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
The bacterial nonheme Fe(II)/2-oxoglutarate (2OG)-dependent enzyme AlkB repairs alkylation damages in single-stranded DNA (ss-DNA) nucleotide bases. This study examines for the first time the reaction mechanism of the AlkB-catalyzed repair of alkylated and exocyclic guanine adducts (GAs) in single-stranded DNA induced by everyday chemical exposures associated with cancers and other genetic disorders. The studied substrates include N2-furfurylguanine (FF-dG), N2-tetrahydrofuran-2-yl-methylguanine (HF-dG), 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-α]purin-10(3H)-one (α-OH-PdG), 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-α]purin-10(3H)-one (γ-OH-PdG), and 3-(2'-deoxy-β-D-erythro-pentofuranosyl) pyrimido[1,2-α]purin-10(3H)-one (M
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