ArticlePloS one2025
Clinical outcomes of a novel single-stage cartilage repair technique using calcified cartilage zone debridement with hyalofast.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aims to determine the clinical outcomes of a new technique of cartilage repair surgery, using calcified cartilage zone debridement coupled with Hyalofast and bone marrow aspirate concentrate, in terms of pain and functional outcomes.
methodsThis was a retrospective case series in 19 patients with cartilage injuries, ICRS 3 and 4. Using arthroscopic examination, cartilage defects were identified and debrided. Then, the calcified cartilage zone was identified and scrapped, until punctate bleeding occurred. Hyalofast was fixed into the defect and bone marrow aspirate concentrate was injected into the Hyalofast. Patients were followed up at baseline, 1, 6, and 18 months post-operative, using visual analog scale, KOOS, IKDC, and Lysholm Score.
resultsThe mean age was 45.33 ± 9.68 years, with the mean cartilage defects of 10.21 ± 11.10 X 9.43 ± 10.85 mm2. Among the cohort, seven patients (36.8%) underwent three chondral repair procedures, five (26.4%) received two procedures, and the remaining seven (36.8%) were treated with a single procedure. In the KOOS subscale, there was a steady improvement; symptoms (mean difference: -23.87, CI: -43.97 - -3.77, p-value = 0.015), pain (mean difference: -28.39, CI: -43.94 - -12.83, p-value = 0.001), activity of daily living (mean difference: -26.23, CI: -40.95 - -10.14, p-value = 0.001), and sports subscale (mean difference: -57.36, CI: -80.76 - -33.97, p-value < 0.001).
conclusionThe calcified cartilage zone debridement technique served as a novel technique to preserve subchondral plate allowing better outcomes for cartilage repair.
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