ArticlePLoS neglected tropical diseases2025
Epidemiological characteristics of human-to-human transmission of severe fever with thrombocytopenia syndrome in China from 1996 to 2023.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Phylogeographic epidemiology of Dabie bandavirus in East Asia: divergent transmission networks and genotype‑linked clinical severity.Infectious diseases of poverty · 2026Article
- Environmental, climatic, and social risk factors of severe fever with thrombocytopenia syndrome and the implications of climate change.One health (Amsterdam, Netherlands) · 2026Article
- Modeling the role of environmental and socioeconomic factors in endemic SFTS risk using a multicomponent framework.One health (Amsterdam, Netherlands) · 2026Article
- Research progress on antiviral drugs and vaccines for severe fever with thrombocytopenia syndrome.Frontiers in immunology · 2026Review
- Implementing a Multidimensional Nursing Protocol in Dabie Bandavirus-Induced SFTS With Critical Complications.Clinical case reports · 2025Article
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8 authors.
Funding
Abstract
backgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease transmitted mainly through the bite of Haemaphysalis longicornis, and can cause clusters through contact transmission, and its incidence shows a rising and spreading trend in China. This study aimed to analyze the occurrence process of human-to-human transmission clusters and provide evidence for effective implementation of interventions.
methodsData about SFTS human-to-human transmission clusters were extracted from 42 published articles. R 4.4.1 and Microsoft Excel software were used to process and analyze the epidemiological and clinical data extracted.
results37 clusters occurring from 1996 to 2023 were retrieved, of which 2 (5.41%) involved third-generation transmission, 7 (18.92%) involved 16 asymptomatic infections, and 9 (24.32%) involved 17 medical personnel. There were 37 index cases with a case fatality rate of 97.30%, 135 secondary cases with a case fatality rate of 12.40%, and an overall of 31.33%. The first treatment of the index case was mainly in primary medical institutions (24, 64.86%) and the most common symptoms were fever, fatigue and gastrointestinal symptoms. The index cases were distributed from March to October each year, the peak was from April to July, and the incubation period was 5-21 days, mostly in middle-aged and elderly farmers. Clusters were mainly distributed in Jiangsu Province (9 clusters), followed by Henan, Shandong and Zhejiang Provinces (6 clusters each). The clusters occurred mostly in the progress of care (72.97%), funeral (64.86%) and treatment of patients (24.32%), involving relatives (75.76%), medical workers (12.12%), villagers (9.85%) and morticians (2.27%). Almost all clusters were spread by contact with patients' blood and bloody secretions (97.30%).
conclusionsSFTS human-to-human transmission clusters sometimes occur in China, with a high case fatality rate. It is necessary to strengthen public health education, and improve the early diagnosis and treatment ability of medical workers, to avoid nosocomial infection or family (community) transmission.
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