ArticleNeuropsychology2026
Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.
Article in Neuropsychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveLiterature concerning the structural brain correlates of verbal memory in aging with multiple sclerosis (MS) is scarce. This study addressed this gap by examining the impact of white matter microstructure and macrostructure on verbal memory in older adults with and without MS.
methodParticipants were 64 older adults with MS (OAMS; age
resultsAdjusted moderation models revealed that OAMS showed lower HVLT-R total immediate recall compared to controls in the presence of higher lesion volume in the bilateral fornices, left uncinate fasciculus, and right ventral cingulum, and lower HVLT-R delayed recall in the presence of lower fractional anisotropy in the right ventral cingulum and higher lesion volume in the left uncinate fasciculus and right ventral cingulum, with small effect sizes (interaction term Δ
conclusionsRecall was lower in OAMS when limbic tract white matter had lower integrity and higher lesion load. Findings suggest that the influence of MS on verbal memory in older adults is related, in part, to underlying white matter disruptions in tracts implicated in memory. While the sample was generally representative of the U.S. MS population (majority White women), generalizability is limited and warrants further research. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
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