Evidence map›Paper›PMID 40705457›Full record

ArticlePathogens and disease2025

Characterization of BK polyomavirus-associated nephropathy (BKPyVAN) in kidney transplant recipients using transcriptomic analysis: a comprehensive scoping review.

Lachlan A Davidson, Natalie M Niessen, Matthew Rowlandson, Thida M Myint, Paul R Trevillian, Adrian D Hibberd, Munish K Heer, Jay C Horvat, Katherine J Baines

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lachlan A DavidsonSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia.ORCID 0009-0003-4130-7420
Natalie M NiessenSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia.
Matthew RowlandsonNewcastle Renal Transplant Unit, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Thida M MyintNewcastle Renal Transplant Unit, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Paul R TrevillianHunter Transplant Research Foundation, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Adrian D HibberdHunter Transplant Research Foundation, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Munish K HeerHunter Transplant Research Foundation, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Jay C HorvatSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia.
Katherine J BainesSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia.

Funding

Research Training Program- Australian Goverment
6 · The paper itself

Abstract

BK polyomavirus (BKPyV) infection reactivates with immunosuppressive therapies and can lead to the development of BKPyV-associated nephropathy (BKPyVAN) in kidney transplant recipients. This scoping review assesses the use of transcriptomics to profile BKPyVAN in kidney transplant recipients. The following search strategy was employed in Medline and Embase: 'BK virus' or 'BK polyomavirus' or 'Polyomavirus' AND 'Kidney transplant' or 'Nephritis' or 'Nephropathy' AND 'Gene expression' or 'Transcriptomics' or 'mRNA'. The search identified 368 publications (264 EMBASE and 104 MEDLINE), and after removal of duplicates (92) and abstract/full-text screening, there were 11 eligible studies which included 7 original transcriptomic studies and 4 bioinformatic studies. There was consistent dysregulated expression of proinflammatory pathways (e.g. cytokines, chemokines, T- and B-cell-related pathways) in BKPyVAN compared with stable graft function. There was considerable overlap between the gene expression patterns identified in BKPyVAN and T-cell mediated rejection that require more exploration. This review highlights limitations including small sample sizes, lack of validation, and variation in technical platforms and study designs. Transcriptomics in BKPyVAN is currently underutilized and there is a genuine need for further research in larger cohorts to provide action in discovering novel therapeutic targets and discriminative gene expression signatures to guide individualized therapeutic strategies.

Indexed as

BK VirusGene Expression ProfilingKidney DiseasesKidney TransplantationPolyomavirus InfectionsTranscriptomeTransplant RecipientsTumor Virus InfectionsHumansBK polyomavirusBK polyomavirus-associated nephropathyinfectionkidney transplantscoping reviewtranscriptomics

Identifiers

PMID40705457
PMCPMC13223728

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