Evidence map›Paper›PMID 40705343›Full record

ArticleMedical mycology2025

Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains.

Adepemi Ogundeji, Maryam Bello-Akinosho, Vaughn Swart, Jonathan Featherston, Errol D Cason, Armand Bolsenbroek, Carel Beneke, Jolly Musoke, Tyla Baker, Arshad Ismail and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. In Vitro Acid Resistance of Feline-DerivedJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Article
  4. First report ofMedical mycology case reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adepemi OgundejiDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Maryam Bello-AkinoshoDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Vaughn SwartDepartment of Zoology and Entomology, University of the Free State, Bloemfontein, 9301, South Africa.
Jonathan FeatherstonSequencing Core Facility, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Sandringham, 2192, South Africa.
Errol D CasonDepartment of Animal Sciences, University of the Free State, Bloemfontein, 9301, South Africa.
Armand BolsenbroekDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Carel BenekeDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Jolly MusokeDepartment of Medical Microbiology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9301, South Africa.
Tyla BakerDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Arshad IsmailSequencing Core Facility, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Sandringham, 2192, South Africa.ORCID 0000-0003-4672-5915
Olihile SebolaiDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.ORCID 0000-0002-0182-1084
Jacobus AlbertynDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.
Carolina PohlDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, 9301, South Africa.ORCID 0000-0001-6928-5663

Funding

National Research Foundation of South Africa FBIS2204062196
6 · The paper itself

Abstract

The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.

Indexed as

Antifungal AgentsCandida aurisDrug Resistance, FungalFluconazoleGrasshoppersAnimalsGenome, FungalHumansMicrobial Sensitivity TestsPhylogenyPolymorphism, Single NucleotideWhole Genome SequencingAntifungal AgentsFluconazoleCandidozyma (Candida) aurisdisinfectantsenvironmental nichefluconazoleLocustana pardalinaOne Healthstress tolerance

Identifiers

PMID40705343
PMCPMC12342545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.